Author's response to reviews Title: Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study Authors:

Author's response to reviews Title:Gene-environment Interaction Effects on Lung Function- A Genome-Wide Association Study within the Framingham Heart Study Authors:

Author's response to reviews Title: Heritability of Cardiovascular Risk Factors in a Brazilian Population: Baependi Heart Study Authors:

Author's response to reviews Title: Correlation of Renin Angiotensin and Aldosterone System Activity with Subcutaneous and Visceral Adiposity: the Framingham Heart Study Authors:

Author's response to reviews Title: Genome Wide Association Study to Predict Severe Asthma Exacerbations in Children using Random Forests Classifiers Authors:

Using Genome Wide Estimates of Heritability to Examine the Relevance of Gene-Environment Interplay

We use genome-wide data from the third generation respondents of the Framingham Heart Study to estimate heritability in body mass index using different quantities of the measured genotype. Heritability decreases rapidly when SNPs implicated by a genome-wide association study are removed but shows essentially no decline when SNPs implicated by a gene-environment interaction in a second genome-wi...